Liverpool are facing concerns over Roberto Firmino, Alisson and Fabinho all joining up with Brazil after a national call-up.
The South American World Cup qualifiers get underway next month and Brazil will take on Bolivia and Peru.
But the latter of those countries has been deeply affected by the coronavirus pandemic.
It has Liverpool chiefs concerned that three of their key players could return with the virus.
South American World Cup qualifiers have been postponed from as far back as March.
They were supposed to go ahead last month but FIFA intervened to further put the brakes on matches taking place.
Peru have placed strict measures throughout the country, including a 11 pm curfew.
They only received confirmation from CONMEBOL that they could delay the kick-off between them and Brazil
It was supposed to go ahead at 7:15 pm but they are now allowed to kick-off two hours later.
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That has been done in a bid to keep fans from congregating in public places to watch the match, with the curfew set to kick in before the match can end.
Regardless, Liverpool officials are concerned that their players could be affected by Covid-19 if they leave their protective 'bubbles'.
But the Reds are not the only Premier League club who could be hit with potential coronavirus cases.
Chelsea, Manchester City and Aston Villa all also have players called up to the Brazil squad.
Thiago Silva, Gabriel Jesus and Douglas Luiz could all take part against Peru and Bolivia next month.
International duties have taken place despite the ongoing spread of the virus, including Nations League matches earlier this month.
And the next break is only a week away while the next one will also take place a month after that.
Prem clubs are growing more and more concerned, especially considering the massive fixture pile-up the later season date has caused.
With further positive cases, squads that are already stretched wide and thin could be affected even more.
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