With fellow right-sided defender Kyle Walker also doubtful for the tournament after undergoing groin surgery, James could also have been a contender to start on the right of the back-three that Southgate had been expected to favour at the tournament.
Alongside James and Walker, Kieran Trippier and Trent Alexander-Arnold also featured in the squad for England’s fixtures in September.
Neither player featured in either game, with Alexander-Arnold one of five players omitted from the group retained for the Germany match.
Kieran Trippier
The injuries ahead of him would appear to put Trippier currently ahead in the right-back pecking order, particularly with Alexander-Arnold another to have recently been hampered.
Ben White
Among those outside the squad, White has started the season in excellent form for Arsenal after a consistent run of games on the right of Mikel Arteta’s four-man defence, and could be a fit on the right of a back-three.
Kyle Walker-Peters
Southampton’s Walker-Peters earned his first two England caps against Switzerland and the Ivory Coast and could contend for a place in the squad.
James Justin
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The versatile Justin made his debut in June but has endured a difficult start to the season with Leicester, who are bottom of the Premier League.
In addition to the opening fixture against Iran, England face the USA and Wales in Group B.
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